منابع مشابه
The yin and yang of MeCP2 phosphorylation.
S tudies of the childhood neurological disorder Rett syndrome and methyl-CpG-binding protein 2 (MeCP2) taught us that MeCP2 performs a balancing act in modulating neurological functions. Rett syndrome, characterized by cognitive deficits, motor impairments, autistic-like features, seizures, and stereotyped repetitive hand movements is caused by loss of MeCP2 function (1). On the other hand, a s...
متن کاملMemory mechanisms: The yin and yang of protein phosphorylation
Protein phosphorylation has long been known to play a key role in triggering the synaptic changes underlying learning and memory. Recent studies highlight the importance of tightly regulated dephosphorylation as a mechanism controlling the induction of long-term synaptic change and lasting memory.
متن کاملProtein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
A system which consisted of multidimensional liquid chromatography (Yin-yang MDLC) coupled with mass spectrometry was used for the identification of peptides and phosphopeptides. The multidimensional liquid chromatography combines the strong-cation exchange (SCX), strong-anion exchange (SAX), and reverse-phase methods for the separation. Protein digests were first loaded on an SCX column. The f...
متن کاملYin yang
oxidative Medicine and celluar Longevity 227 Derived from classical Chinese philosophy and with frequent applications in Chinese medicine, " yin yang " has grown into an interesting concept that may have a number of applications. The term is usually used to depict the existence of polarizing or opposing forces in nature. Yet, the concept of " yin yang " can be much more involved, especially in ...
متن کاملPlatelets: yin and yang.
In this issue of Blood, Boulaftali and colleagues have made the important and novel observation that deficiency of the serine protease inhibitor (serpin), PN-1, in platelets results in a prothrombotic state, supporting the role of platelet PN-1 in thrombosis.1 Specifically, Boulaftali et al have initially confirmed previously published studies by Gronke et al indicating that protease nexin-1 (P...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0901518106